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Molecular Characterization and Correlation with β-lactam Resistance of Streptococcus pneumonia Isolates in Hangzhou, China / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences ; (12): 389-393, 2018.
Article in English | WPRIM | ID: wpr-690645
ABSTRACT
Penicillin-binding proteins (PBPs) are the target of β-lactam antibiotics (the major treatment for Streptococcus pneumoniae infections), and mutations in PBPs are considered as a primary mechanism for the development of β-lactam resistance in S. pneumoniae. This study was conducted to investigate the mutations in the PBPs of clinical S. pneumoniae isolates in Hangzhou, China, in correlation with β-lactam resistance. Results showed that 19F was the predominant serotype (7/27) and 14 of the S. pneumoniae isolates were resistant to both penicillin G and cephalosporin. Genotyping results suggested that β-lactam-resistant isolates primarily exhibited single-site mutations in both the STMK and SRNVP motifs of pbp1a in combination with double-site mutations in the STMK motif of pbp2x, which might be the primary mechanisms underlying the β-lactam resistance of the isolates in this study.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Pneumococcal Infections / Streptococcus pneumoniae / China / Epidemiology / Drug Resistance, Bacterial / Beta-Lactams / Genetics / Microbiology / Anti-Bacterial Agents Limits: Humans Country/Region as subject: Asia Language: English Journal: Biomedical and Environmental Sciences Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Pneumococcal Infections / Streptococcus pneumoniae / China / Epidemiology / Drug Resistance, Bacterial / Beta-Lactams / Genetics / Microbiology / Anti-Bacterial Agents Limits: Humans Country/Region as subject: Asia Language: English Journal: Biomedical and Environmental Sciences Year: 2018 Type: Article