A Case of Villous Adenoma with Depletion Syndrome / 대한소화기내시경학회지

ABSTRACT

Massive secretory diarrhea with pre-renal insufficiency, hyponatremia, hypokalemia and metabolic alkalosis or acidosis is associated with some large villous adenomas of the rectum and is called with depletion syndrome. This characteristic fluid and electrolyte depletion syndrome is caused by secretion of sodium, potassium, and fluid from the tumor. PGE2 formation in the villous adenoma appears to be the cause of fluid secretion by the abnormal tumor epithelium. Surgical removal of villous adenoma is the only promising therapy, In case of inoperability, denial of surgical intervention or just for palliative treatment prior to surgery, the use of PG synthetase inhibitors may facilitate the correction of severe fluid-electrolyte deficits. We reported a case of large villous adenoma of the rectum with depletion syndrome aceompanied by secretory diarrhea and fluid and electrolyte depletion with metabolic alkalosis due to severe vomiting.