The Role of Fibrocyte in the Pathogenesis of Silicosis / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 311-316, 2018.
Article
in En
| WPRIM
| ID: wpr-690655
Responsible library:
WPRO
ABSTRACT
Exposure to free silica induces silicosis and myofibroblasts are regarded as primary effector cells. Fibrocytes can differentiate into myofibroblast. Therefore, the present study was designed to investigate whether fibrocytes participate in silicosis. The rat model of silicosis was established. Hematoxylin-eosin stainings and Masson stainings were used to evaluate the histopathology and collagen deposition. Flow cytometry and immunofluorescence were performed to detect the number of fibrocytes and their contribution to myofibroblasts. Results showed that fibrocytes participate in silicosis. Trend analysis of different sources of myofibroblasts during silicosis indicated that fibrocytes and lung type II epithelial cell-derived myofibroblasts play an important role in the early stage of silicosis, while resident lung fibroblast-derived myofibroblasts play a predominant role during the fibrosis formative period.
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Silicosis
/
Random Allocation
/
Rats, Sprague-Dawley
/
Silicon Dioxide
/
Cell Biology
/
Disease Models, Animal
/
Toxicity
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Myofibroblasts
/
Lung
Type of study:
Etiology_studies
Limits:
Animals
Language:
En
Journal:
Biomedical and Environmental Sciences
Year:
2018
Type:
Article