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Combined Influence of Insulin Resistance and Inflammatory Biomarkers on Type 2 Diabetes: A Population-based Prospective Cohort Study of Inner Mongolians in China / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences ; (12): 300-305, 2018.
Article in English | WPRIM | ID: wpr-690657
ABSTRACT
This prospective study was designed to examine the combined influence of insulin resistance (IR) and inflammatory biomarker levels on type 2 diabetes mellitus (T2DM) among 1,903 Inner Mongolians. During follow-up, 205 (10.77%) participants developed T2DM, and the incidence of T2DM was higher among subjects with IR, elevated C-reactive protein (CRP), elevated sICAM-1, elevated sE-selectin, or the coexistences of IR with elevated CRP, elevated sICAM-1, elevated sE-selectin, and elevated angiotensin II (all P < 0.05) compared with patients without IR or any elevated biomarkers. In multivariate analysis, the odd ratios [OR, (95% confidence intervals)] for these conditions were 1.944 (1.405-2.691), 2.003 (1.449-2.767), 1.706 (1.232-2.362), 1.560 (1.123-2.165), 2.708 (1.809-4.054), 1.885 (1.155-3.078), 2.101 (1.340-3.295), and 2.260 (1.426-3.582), respectively. Our findings demonstrated that IR and elevated inflammatory biomarkers were associated with T2DM, and that the coexistence of IR and elevated inflammatory biomarkers increased the risk of T2DM.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Physiology / Blood / Insulin Resistance / Biomarkers / Odds Ratio / China / Epidemiology / Multivariate Analysis / Prospective Studies / Cohort Studies Type of study: Etiology study / Incidence study / Observational study / Risk factors Limits: Humans Country/Region as subject: Asia Language: English Journal: Biomedical and Environmental Sciences Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Physiology / Blood / Insulin Resistance / Biomarkers / Odds Ratio / China / Epidemiology / Multivariate Analysis / Prospective Studies / Cohort Studies Type of study: Etiology study / Incidence study / Observational study / Risk factors Limits: Humans Country/Region as subject: Asia Language: English Journal: Biomedical and Environmental Sciences Year: 2018 Type: Article