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Relationship between Early Peak Temperature and Neutropenia Duration in Acute Leukemia Patients after Chemotherapy and Its Mechanism / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 665-670, 2018.
Article in Chinese | WPRIM | ID: wpr-690931
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between early peak body temperature and neutropenia duration and its potential mechanism.</p><p><b>METHODS</b>A total of 111 patients with CR1 phase acute leukemia (AL) with neutropenia infection were enrolled in this study. The relationship between early peak body temperature and neutropenia duration was analyzed retrospectively, and the IL-6 serum level in patients with different peak of body temperature was detected, and the single cell culture system in vitro was established, the incorparation rate of EdU in vivo was detected, and the effect of IL-6 on mouse hematopoietic stem cells /progenitor cells was analyzed.</p><p><b>RESULTS</b>Out of 111 patients with nentropenia, the body temperature <38 °C and the neutropenia duration 9.5±3.69 d were observed in 44 patients, while the body temperature >38 °C and neutropenia duration 7.33±4.20 d were observed in 69 patients, the differences between 2 groups was statistically signficant (P<0.05). The EdU test showed that the number of EdU hematopoietic stem cells and progenitor cells increased. The IL-6 level was different in patients with different peaks of initial bady temperature (P<0.05). The results of amimal experiment showed that the IL-6 could promote the proliferation of hematopoietic stem cells/ progenitor cells in vitro and in vivo.</p><p><b>CONCLUSION</b>For patients with neutropenic infection when initial body temperature peak is <38 °C, the probability of neutropenia duration prolonging after chamotherapy increases, which may relate with promotive effect of pro-inflammatory cytokins on prliferation of hematopoietic stem cells/progenitor cells.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Temperature / Hematopoietic Stem Cells / Leukemia / Acute Disease / Retrospective Studies / Neutropenia Type of study: Observational study Limits: Animals / Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Temperature / Hematopoietic Stem Cells / Leukemia / Acute Disease / Retrospective Studies / Neutropenia Type of study: Observational study Limits: Animals / Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2018 Type: Article