Research on Ralation of Long Non-coding RNA with Diffuse Large B-cell Lymphomas -Review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 609-614, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-690941
ABSTRACT
Diffuse large B-cell lymphoma (DLBCL) accounts for approximately 30% of the non-Hodgkin's lymphoma patients. The underlying molecular mechanism of its pathogenesis is not well defined and the survival rate of DLBCL patients is very low. Moreover, the annual incidence and mortality of DLBCL is still rising. Accordingly, identification and characterization of new molecular pathways of DLBCL will lead to the development of novel diagnostic markers and molecular therapeutic targets. Long non-coding RNAs (LncRNA) are non-coding RNAs with a length greater than 200 bp in eukaryotic cells, which can regulate the expression of their target genes at the transcriptional and post transcriptional levels. The function of LncRNAs is involved in the initiation, progression, invasion and metastasis of many cancers. Recently, the role of LncRNAs in DLBCL has been identified and intensely studied. This review summarizes the recent discoveries in the expression and function of LncRNAs including HULC,PEG10,LincRNA-p21,HOTAIR,LUNAR1,MALAT1 and SubSigLnc-17 in DLBCL, so as to find potential diagnostic biomarkers and therapeutic targets for DLBCL.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Genes, Regulator
/
Lymphoma, Large B-Cell, Diffuse
/
Cell Line, Tumor
/
RNA, Long Noncoding
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2018
Type:
Article
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