Research Progress of β-catenin in Chronic Myelogenous Leukemia -Review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 600-602, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-690943
ABSTRACT
β-catenin is an important member of Wnt signaling pathway. With more and more research on the relationship between β-catenin and cancers, it is noted that the concentration of β-catenin in cells is not only the landmark of activating the Wnt signaling pathway, but also a common phenomenon in various tumor cells. Moreover, abnormal expression of β-catenin is reported in blastic phase of CML and IM-resistant CML. Besides, β-catenin inhibitor is proved to be effective for the improvement of the IM susceptibility and the postponment of blastic phase. Here is to make a brief review about the mechanisms of β-catenin in the treatment of CML, such as classical signaling pathways as well as new genes and pathways.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/
Beta Catenin
/
Wnt Signaling Pathway
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2018
Type:
Article
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