Current Understanding of Myeloproliferative Neoplasm-Related Gene Mutations and Cytokine -Review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 589-594, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-690945
ABSTRACT
Myeloproliferative neoplasm(MPN) is clonal hematopoietic stem cell disorder characterized by abnormal proliferation and expansion of one or more myeloid lineages. BCR-ABL-negative MPN includes polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF). The mutations of JAK2, CALR and MPL genes are involved in the pathogenesis of MPN that provided a more complete molecular diagnostic standard for MPN. More and more new mutated genes related to prognosis of MPN were discovered in the past few years, at same time it was found that cytokines were also involved in the genesis and development of MPN. These provide a theoretical basis for the diagnosis, risk stratification and treatment management of MPN. In this article, the mechanisms of MPN-related cytokines and mutated genes in the genesis and development of disease and prognosis characteristics are summarized.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Cytokines
/
Calreticulin
/
Janus Kinase 2
/
Thrombocythemia, Essential
/
Mutation
/
Myeloproliferative Disorders
Type of study:
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2018
Type:
Article
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