Significance of Retinol-Binding Protein Expression in Patients with Acute Myeloid Leukemia / 中国实验血液学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the expression of retinol-binding protein (RBP) in patients with acute myeloid leukemia (AML) and its related factors.</p><p><b>METHODS</b>The clinical data of 123 patients with AML from October 2012 to February 2016 and 100 healthy controls were collected and the correlation of RBP expression level with sex, French-American-British (FAB) subtypes, molecular mutations, peripheral white blood cells and long-term outcomes was analyzed.</p><p><b>RESULTS</b>Compared with AML patients, the RBP expression level was significantly higher in healthy controls (61.02±34.97 vs 34.44±14.08 mg/L)(u=8.658, P<0.01). Patients with M3 showed higher RBP level (40.74±15.79 mg/L) compared with that of M4 (28.40±13.64 mg/L)(P<0.01) and M5 (31.97±15.31 mg/L)(P<0.05). Negative correlation was observed for RBP and white blood cells in patients with AML (r=-0.352, P<0.001), which was more remarkable in patients with M4 (r=-0.563, P<0.01) and M5 (r=-0.423, P<0.01). AML patients achieved complete remission (CR) (48.64±9.24 mg/L) showed higher RBP level than that before treatment (u=4.876, P<0.01), but lower than healthy controls (u=2.106,P<0.05). After CR, patients with M3 showed higher RBP level than that of non-M3 patients (54.91±5.25 mg/L vs 41.36±7.33 mg/L)(t=8.777,P<0.01).</p><p><b>CONCLUSION</b>Detecting RBP expression may provide some useful information for urderstanding the pathophysiology and improving the treatment of patients with AML.</p>