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Influencing Factors of Nosocomial Infection after Chemotherapy in Adult Patients with Acute Myeloid Leukemia and Its Control Strategy / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 412-416, 2018.
Article in Chinese | WPRIM | ID: wpr-690975
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the influencing factors of nosocomial infection in adult patients with acute myeloid leukemia (AML) and its control strategies.</p><p><b>METHODS</b>The clinical data of 109 patients with AML treated in our hospital from June 2014 to June 2017 were retrospectively analyzed. The clinical factors were analyzed retrospectively, and the influencing factors of infection after chemotherapy were explored.</p><p><b>RESULTS</b>A total of 109 patients received chemotherapy for 267 case-times, the infection occurred in 168 case-times, the nosocomial infection rate was 62.92%, the main affected sites included upper respiratory tract and lung. 155 samples from 168 case-times infection patients were collected and cultured, 32 pathogens were obtained with a positive rate 20.6% (32/155), including 14 Gram-negative bacteria, 9 Gram-positive bacteria and 4 strains of fungi and 5 strains of other pathogens. Statistics showed that the patient's age over 40 years old, hospitalization in spring and summer, glucocorticoid therapy, high intensity chemotherapy, neutrophil count, white blood cell count and hemoglobin content were the independent risk factors for infection after chemotherapy in AML patients (P<0.05).</p><p><b>CONCLUSION</b>The age of more than 40 years old, hospitalization in spring and summer, glucocorticoid therapy, high-intensity chemotherapy, white blood cell count, neutrophil count and hemoglobin content are the independent risk factors for infection after chemotherapy in the AML patients with the above-mentioned characteristics, they should be closely monitored, and chemotherapy intensity should be controled, so as to control the occurrence of infection; and in the event of infection, a timely powerful anti-infective treatment would be indispensable.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Leukemia, Myeloid, Acute / Cross Infection / Retrospective Studies / Risk Factors / Hospitalization Type of study: Etiology study / Observational study / Risk factors Limits: Adult / Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Leukemia, Myeloid, Acute / Cross Infection / Retrospective Studies / Risk Factors / Hospitalization Type of study: Etiology study / Observational study / Risk factors Limits: Adult / Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2018 Type: Article