Your browser doesn't support javascript.
loading
Imatinib as Second-Line Treatment Drug for CML Patients Intolerant to Nilotinib / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 407-411, 2018.
Article in Chinese | WPRIM | ID: wpr-690976
ABSTRACT
<p><b>OBJECTIVE</b>To explore the individualized treatment for patient with chronic phase chronic myeloid leukemia(CML-CP).</p><p><b>METHODS</b>The clinical data and treatment process of one CML-CP patient which intolerated to nilotinib were analyzed.</p><p><b>RESULTS</b>Nilotinib was given to the patient once the diagnosis of CML-CP was set. Although major molecular remission (MMR) and complete cytogenetic remission (CCyR) were obtained during treatment for 3 months, a grade 3-4 hepatotoxicity appeared in the course of treatment.With drug reduction and symptomatic treatment, nilotinib was discontinued after 3 withdrawals and replaced with imatinib in January 11, 2015. The patients achieved MMR and CCyR at 7 months after imatinib replacement. At present, the patient tolerated well without any adverse events.</p><p><b>CONCLUSION</b>Imatinib can be used as a second-line treatment drug for CML patients who was intolerant to nilotinib, and with less adverts, good effect and so on.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Piperazines / Pyrimidines / Benzamides / Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Treatment Outcome / Drug Resistance, Neoplasm / Protein Kinase Inhibitors / Imatinib Mesylate / Antineoplastic Agents Limits: Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2018 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Piperazines / Pyrimidines / Benzamides / Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Treatment Outcome / Drug Resistance, Neoplasm / Protein Kinase Inhibitors / Imatinib Mesylate / Antineoplastic Agents Limits: Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2018 Type: Article