Your browser doesn't support javascript.
loading
Chinese Medicine Amygdalin and β-Glucosidase Combined with Antibody Enzymatic Prodrug System As A Feasible Antitumor Therapy / 中国结合医学杂志
Article in English | WPRIM | ID: wpr-691402
Responsible library: WPRO
ABSTRACT
Amarogentin is an efficacious Chinese herbal medicine and a component of the bitter apricot kernel. It is commonly used as an expectorant and supplementary anti-cancer drug. β-Glucosidase is an enzyme that hydrolyzes the glycosidic bond between aryl and saccharide groups to release glucose. Upon their interaction, β-glucosidase catalyzes amarogentin to produce considerable amounts of hydrocyanic acid, which inhibits cytochrome C oxidase, the terminal enzyme in the mitochondrial respiration chain, and suspends adenosine triphosphate synthesis, resulting in cell death. Hydrocyanic acid is a cell-cycle-stage-nonspecific agent that kills cancer cells. Thus, β-glucosidase can be coupled with a tumor-specific monoclonal antibody. β-Glucosidase can combine with cancer-cell-surface antigens and specifically convert amarogentin to an active drug that acts on cancer cells and the surrounding antibodies to achieve a killing effect. β-Glucosidase is injected intravenously and recognizes cancer-cell-surface antigens with the help of an antibody. The prodrug amarogentin is infused after β-glucosidase has reached the target position. Coupling of cell membrane peptides with β-glucosidase allows the enzyme to penetrate capillary endothelial cells and clear extracellular deep solid tumors to kill the cells therein. The Chinese medicine amarogentin and β-glucosidase will become an important treatment for various tumors when an appropriate monoclonal antibody is developed.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Humans / Prodrugs / Beta-Glucosidase / Iridoids / Therapeutic Uses / Cell-Penetrating Peptides / Amygdalin / Antibodies, Monoclonal / Antineoplastic Agents Language: English Journal: Chinese journal of integrative medicine Year: 2018 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Humans / Prodrugs / Beta-Glucosidase / Iridoids / Therapeutic Uses / Cell-Penetrating Peptides / Amygdalin / Antibodies, Monoclonal / Antineoplastic Agents Language: English Journal: Chinese journal of integrative medicine Year: 2018 Type: Article