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Effects of trimetazidine on oxidative stress in dogs with heart failure / 安徽医科大学学报
Acta Universitatis Medicinalis Anhui ; (6): 908-912, 2018.
Article in Chinese | WPRIM | ID: wpr-691440
ABSTRACT
Objective To investigate the effect of trimetazidine on oxidative stress and morphological structure of cardiomyocytes in dogs with heart failure. Methods A model of heart failure was established by rapid pacing, and 15 dogs were randomly divided into 3 groups sham operation group, model group, trimetazidine group [ intragastric administration trimetazidine 5 mg/( kg·d) ] for 6 weeks. At the end of the experiment, the left ventricular myocar-dium was removed and the malondialdehyde ( MDA) was determined by thiobarbital method. The superoxide dis-mutase ( SOD) was determined by xanthine oxidase method, and the pyruvate was determined by RT-PCR, then the pathomorphology and myocardial ultrastructure was observed. Results The activity of SOD was increased but the expression of MDA were decreased in the myocardium of tramadiazine group. The expression of pyruvate dehy-drogenase ( PDH) mRNA was up-regulated after treated weith trimetazidine, which was higher than that in model group(P<0.05). The degree of myocardial injury in tramadamide group was lower than that in model group veri-fied by light microscope and electron microscope detection ( P<0.05) . Conclusion Tramadiazine can improve oxidative stress in cardiomyocytes of heart failure dogs. The mechanism may be related to the reduction of nicotin-amide adenine dinucleotide ( NADH) production, indirectly improving the expression of PDH mRNA, improving glucose oxidation, inhibiting lipid peroxidation, improving myocardial energy metabolism.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Acta Universitatis Medicinalis Anhui Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Acta Universitatis Medicinalis Anhui Year: 2018 Type: Article