Ecological executive function characteristics in patients with white matter lesions and its influencing factors / 安徽医科大学学报

ABSTRACT

Objective To investigate the characteristics of the ecological execution function in patients with white matter lesions ( WML) and its influencing factors. Methods 43 cases of magnetic resonance imaging( MRI) find-ings in patients with WML were selected. In the same period, 27 patients who were matched in age and educational level, and brain MRI examination showed normal were selected as the control group. The experimental group and the control group were evaluated by the behavior rating inventory of executive function-adult version ( BRIEF-A) . Results Including the each factor score, global executive composite(GEC), behavioral regulation index(BRI) and metacogniton index( MI) score of WML patients were significantly higher than the control group, the differ-ences were statistically significant (P＜0. 05). In the severe group, the BRI, MI and total score were higher than those in the moderate group and mild group. Compared with the mild group, the BRI, MI and total score in patients with moderate group were notable higher (P＜0. 05). Similarly, the scores of all factors in the severe group were all higher than those in the mild group, and the scores of inhibition, plan and organization were higher than those in the moderate group. There was a significant difference in shift, emotional control, self monitoring, initiation, work-ing memory and organization between the moderate group and the mild group ( P ＜0. 05 ) . There was statistical difference on the scores of each factor, BRI, MI and total score between group deep white matter lesions ( DWML) and group periventricular lesions(PVL) (P＜0. 05). Multiple linear regression analysis showed that the inhibition, emotional control, self-monitoring, MI, initiation, working memory, planning, organization and total score were positively correlated with lesion severity. There was a significant positive correlation between BRI and the level of education and the severity of the disease. At the same time, the BRI was negatively correlated with lesion site. Conclusion The each factor score, BRI, MI and total score of BRIEF-A scale are elevated in WML patients, which is related to the severity of the disease and the site of the lesion.