Survey analysis on cognitive dysfunction in patients with type 2 diabetes mellitus and its influecing factors / 吉林大学学报(医学版)

ABSTRACT

Objective:To explore the status,the risk factors and prevention strategies and measures of cognitive dysfunction in the patients with type 2 diabetes mellitus(T2DM),and the provide the theoretical basis for preventing the mild cognitive impairment(MCI)in the patients with diabetes mellitus. Methods:A total of 192 patients with T2DM who were diagnosed definitely and received hospitalization treatment and accepted the questionnaire willingly were selected as the subjects.The general demographic characteristics,general behavioral characteristics and clinical data were collected.Montreal Cognitive Assessment(MoCA)was used to screen the status of the patients with cognitive impairment,and Activities of Daily Living(ADL)assessment was used to assess the ADL of the patients.Chi-square test,t test and Wilcoxon test were performed to compare the congnitive function between the patients with different features.Multivariable Logistic regression model was used to find the independent influencing factors of MCI in the patients with T2DM.The correlation analysis was used to analyze the relationships between the each module of cognitive function of MoCA and the influencing factors.The P<0.05 was regarded as a statistically significant value. Results:There were 192 patients with T2DM accepted the questionnaire.According to the criteria for cognitive impairment in MoCA,154 of the 192 subjects had MCI,and the incidence of MCI was 80.21%(154/192).Multivariate Logistic regression analysis showed that the elderly and low family per capita monthly income were the risk factors of MCI in the patients with T2DM(P<0.05).The results of correlation analysis between the various modules of MoCA and the influencing factors showed that the age was related strongly to the attention ability(r=-0.334,P<0.05);the family per capita monthly income was strongly related to the visual space ability and executive ability(r=0.322,P<0.05).Conclusion:The incidence of MCI in the patients with T2DM is serious. Age and the per capita monthly income of family are the important factors affecting the cognitive function of the patients with T2DM,which mainly affect the visual space ability, executive ability,attention ability,and memory function.