Analysis of misdiagnosis of histiocytic necrotizing lymphadenitis / 白血病·淋巴瘤

ABSTRACT

The histiocytic necrotizing lymphadenitis (HNL) is a common benign lesion in the clinic. Because of its specificity, it is easy to be misdiagnosed as lymphoma or other benign lesions. The author analyzed the reasons of misdiagnosis as follows (1) pathologists ignored the background of reactive hyperplasia and the specificity of clinical pathological changes; (2) isolate one-sided understanding of nuclear debris in necrotic foci; (3) a false negative result could be presented in HNL gene rearrangement analysis. The pathologists must fully grasp the clinical and histopathological features and immunophenotypic characteristics of HNL to prevent the misdiagnosis.