Role of EGFL-7 mediated promoting angiogenesis effect in infantile hemangioma and intervention analysis / 重庆医学

ABSTRACT

Objective To explore the role of EGFL-7 mediated promoting angiogenesis effect in infantile hemangioma and in-tervention measures.Methods Fifty paraffin tissue specimens from infantile hemangioma in this hospital from February 2013 to March 2016 were collected and divided into the hyperplasia stage group,fading stage group and fading complete stage group accord-ing to the different pathological stages.The tissue samples conducted HE staining.The EGFL-7 generation situation in the patho-logical sample was detected.Thirty cases of hyperplasia stage hemangioma treated at the same period were selected as the research subjects.The propranolol intervention treatment was adopted.The EGFL-7 expression changes in serum and urine were detected before and after treatment.Results In the tissue section of hyperplasia stage hemangioma,the lumen was not obvious,the vascular structure was disorder with large nucleus,deep staining,disordered arrangement of endothelial cells.The expression of EGFL-7 in the hyperplasia stage and fading stage was higher than that in the fading complete stage group and normal skin,the difference was statistically significant(P<0.05).The EGFL-7 expression difference between the fading complete stage and normal skin had no statistical significance(P>0.05).Serum and urine EGFL level after propranolol intervention in hemangioma infants was lower than that before treatment,the difference was statistically significant(P<0.05).Conclusion The EGFL-7 level is significantly decreased after propranolol intervention,which may become the important mechanism of hemangioma intervention.