Study on correlation between insulin resistance and new vertebral facture risk after percutaneous vertebroplasty / 重庆医学

ABSTRACT

Objective To investigate the relationship between new vertebral fracture after percutaneous vertebroplasty (PVP) and insulin resistance (IR).Methods A total of 148 patients with osteoporotic vertebral compression fracture in our hospital from June 2013 to June 2016 were included,which were divided into the new fracture (NF) group and postoperative non-fracture control (NC) group.The patient's general information was collected.HOMA-IRindex was calculated by adopting the homeostatic model assessment formula,IR was defined as HOMA-IR≥1.73.The patients with IR were further divided into the low IR group (HO-MA-IR＜2),middle IR group (HOMA-IR 2-6) and high IR group (HOMA-IR＞6).The T value of bone mineral density (BMD) was tested by the dual-energy X-ray absorptiometry,and body mass index (BMI) was calculated according to height and weight.Results Excluding the patients losing follow-up,128 cases were finally included in this study.A total of 48 cases (37.5％) were suffered from new vertebral fracture during follow-up.The morbidity in the NF group was significantly higher than that in the NC group,moreover the HO-MA-IR value was significantly increased (P＜0.05).The IR subgroup analysis showed that with the increasing of IR,the HOMA-IR value and incidence rate of new fracture was increased,however BMI had no statistical difference among 3 subgroups (P＞0.05).The further Pearson correlation analysis showed that the HO-MA-IR value was negatively correlated with the T value (r=-0.361,P=0.027),and positively correlated with the incidence rate of new fracture (r=0.413,P=0.015).Conclusion The risk of new vertebral fracture occurrence after PVP in the patients with IR is increased,which could be considered as an anticipate risk factor.