Correlation between serum MCP-1 and CRP levels with elderly coronary heart disease / 重庆医学

ABSTRACT

Objective To investigate the correlation between the levels of serum MCP-1 and CRP with elderly coronary heart disease(CHD).Methods A total of 200 elderly patients with CHD in this hospital from January 2014 to January 2016 served as the observation group and contemporaneous 200 healthy elderly people as the control group.Then the correlation between the levels of serum MCP-1 and CRP with the degree of coronary artery stenosis and coronary collateral formation was analyzed.The correlations between the mRNA levels of MCP-1 and CRP in monoeytes with the levels of serum MCP-1 and CRP was analyzed.Results The levels of serum MCP-1 and CRP in the observation group were significantly higher than those in the control group(P＜0.05),but the both did not affect the degree of coronary artery stenosis.The number of the patients with coronary collateral formation in the observation group was significantly more than that in the control group(P＜0.05).In different classifications,the levels of serum MCP-1 and CRP in the observation group were significantly higher than those in the control group(P＜0.05);the mRNA levels of MCP-1 and CRP in monocytes of the observation group were dramatically higher than those in the control group(P＜0.05).The correlation analysis showed that the mRNA levels of MCP-1 and CRP in monocytes of CHD patients were positively correlated with levels of serum MCP-1 and CRP,respectively.Moreover,the levels of TG and TC in the patients with CHD were positively correlated with levels of serum MCP-1 and CRP.Conclusion The levels of serum MCP-1 and CRP are positively correlated with coronary collateral grades in CHD patients.The higher their levels,the more the coronary collateral formation in the elderly CHD patients.