Whether HIF-1α gene 1772C/T polymorphism is a negative predictor of coronary collateral circulation formation in patients with coronary artery disease:a meta-analysis / 重庆医学

ABSTRACT

Objective To evaluate the association between hypoxia inducible factor-1α (HIF-1α)gene 1772C/T polymorphism and coronary collateral circulation formation in the patients with coronary heart disease (CHD).Methods The databases of PubMed,Cochrane Library,CBM,CNKI,VIP and Wanfang databases were comprehensively retrieved.The retrieval time was from the database establishment to January 2017.The case control trials on the relationship between HIF-1α gene 1772C/T polymorphism and coronary collateral circulation formation were collected.The included trials were performed the meta analysis.Results A total of 5 articles were included in analysis with a sample amount of 1 355 cases.The meta analysis suggested that HIF-1α gene 1772C/T polymorphism in 5 genetic models had no significant correlation with coronary collateral formation in CHD patients.The odds ratio(OR) values and 95 ％CI in allele,dominant,recessive,homozygote and heterozygote models were 1.70(0.85-3.39),P=0.134;1.46(0.77-2.77),P=-0.251;1.73(0.75-3.99),P=0.197;1.73(0.74-4.03),P=0.204;1.00(0.72-1.37),P=0.988,respectively.Conclusion HIF-1α gene 1772C/T polymorphism might have no association with coronary collateral formation in CHD patients.