Analysis on correlation between multiple single nucleotide polymorphisms loci and risk of esophageal and gastric cancer / 重庆医学

ABSTRACT

Objective To investigate the association between multiple single nucleotide polymorphisms (SNP) with esophageal and gastric cancer,and to search the shared genetic risk loci for esophageal and gastric cancer in Han population of Henan Province.Methods Five hundreds cases of esophageal cancer,600 cases of gastric cancer and 600 persons undergoing physical examination in the Henan Provincial Tumor Hospital were selected.Seven SNP loci were selected.The genotyping was performed by adopting the Sequenom MassAR-RAY SNP genoting technique.The relative odds ratios(OR) and 95 ％ confidence intervals(CI) were calculated by unconditional logistic regression.Results In allelic model,the two SNP loci were correlated with the risk of esophageal cancer,which were rs4785204 (OR =1.43,95 ％ CI1.12-1.85,P =0.01) and rs4924935 (OR =0.76,95 ％CI0.61-0.99,P=0.04).The four SNP loci were correlated with the risk of gastric cancer,gastric cancer,which were rs13361707(OR=1.23,95％CI1.13-1.56,P=0.00),rs4779584(OR=1.25,95％CI1.11-1.58,P=0.04),rs4785204(OR=1.24,95％CI1.03-1.49,P=0.03)and rs4924935(OR=0.76,95％ CI0.60-0.99,P =0.04).In the genetic model analysis,the four loci were significantly correlated with the risk of esophageal cancer,which were rs6687758,rs401681,rs4785204 and rs4924935(P＜0.05);the three loci were correlated with the gastric cancer,which were rs13361707,rs4779584 and rs4785204(P＜0.05).Conclusion Multiple SNP loci have the relationship with the risk of esophageal and gastric cancer in Han population of Henan Province.The genetic variation of rs4785204 and rs4924935 loci may simultaneously play an important role in the occurrence and development of esophageal and gastric cancer.