Clinical effect of individualized dose of rivaroxaban for thrombus prevention after hip arthroplasty / 重庆医学

ABSTRACT

Objective To explore the efficacy and safety of adjusting rivaroxaban dose for preventing deep vein thrombosis(DVT) according to extreme body mass in the patients with orthopedic surgery.Methods One hundred and two patients undergoing the first time total hip arthroplasty(THA) from January 2014 to December 2016 included 102 cases of body mass ＜50 kg and 27 cases of body mass ＞100 kg,which were divided into the experimental subgroup and control subgroup respectively.Each subgroup was given different doses of rivaroxaban for 35 d.The coagulation function,hemoglobin,D-dimer change,bleeding events and VTE incidence rate were recorded.Results The extension values of PT and APTT had no statistically significant difference between the experimental group and control group(P＞0.05).Hb and PLT in the ＜50 kg group were decreased,and the incision drainage amount was less than that in the ＜50 kg group,the intra-group comparison in the ＞100 kg group had no statistical difference (P＞0.05).All cases had no bleeding in other sites.The difference of DVT and PE occurrence had no statistical significance(P＞0.05).Conclusion Adjusting the rivaroxaban dose according to the extreme body mass can effectively prevent the DVT occurrence after orthopedic operation and reduces the occurrence rate of adverse drug reactions.