Effect of hemodialysis on imbalance of Treg and Th17 levels in patients with uremia / 重庆医学

ABSTRACT

Objective To investigate the effect of maintenance hemodialysis on regulatory T cells (Treg) and helper T cells (Th17) in uremic patients.Methods One hundred and eighty-five patients with uremia from February 2014 to February 2017 in our hospital were selected,including 102 cases of hemodialysis as the dialysis group and 83 cases without conducting hemodialysis as the non-dialysis group.Contemporaneous 100 healthy volunteers were selected as the control group.The levels of Treg,Th17,interleukin-6 (IL-6),IL-10 and IL-17 were detected in each group.Results The levels of Treg,Th17,IL-6 and IL-17 in the control group were significantly lower than those in the non-dialysis group and dialysis group (P＜0.05),while the level of IL-10 was significantly higher than that in the non-dialysis group and dialysis group (P＜0.05);the levels of Treg,Th17,IL-6 and IL-17 in the dialysis group were (5.02±1.80)％,(20.16±7.04)％,(28.78± 4.18) pg/mL and (40.38±9.03) pg/mL,which were significantly lower than those in the non-dialysis group (P＜0.05),and the IL-10 level in the dialysis group was (18.52±2.19) pg/ml,which was significantly higher than that in the non-dialysis group (P＜0.05).Conclusion The imbalance of Treg and Th17 levels exist in uremic patients,and hemodialysis can help to improve the imbalance of Treg and Th17 levels.