Progress of N-myc downstream regulated gene 2 / 国际儿科学杂志

ABSTRACT

The full name of NDRG2 is N-myc downstream regulated gene 2,which is a member of NDRG.It has a high degree of homology,mainly involved in cell proliferation and differentiation.At present it has been researched mainly as a tumor suppressor gene,in addition,it has participated in the development of embryonic and nervous system,the regulation of water and sodium metabolism in renal proximal tubule and collecting duct by aldosterone aldosterone.It is also involved in the response to stress.This article rewiews the mechanism of transcriptional regulation and molecular interaction.