Research progresses of HMGB1 in viral infection related diseases / 国际儿科学杂志

ABSTRACT

High mobility group protein B1 (high mobility group box 1,HMGB1) is a nuclear protein that is highly conserved,constitutively expressed in various tissues and cells in the nucleus.It participates in gene transcription and replication,which is released into the nucleus mainly as a late cytokine mediated inflammatory immune response.As a result of cell stress,HMGB1 and pathogens including viruses infection are closely related.Recent studies have shown that HMGB1 is involved in the occurrence and development of many kinds of virus related diseases.This paper makes a review of the research progresses.