Anti-infective and immunoregulatory mechanisms of vitamin D in juvenile idiopathic arthritis / 国际儿科学杂志

ABSTRACT

Juvenile idiopathic arthritis is a common chronic rheumatic disease in childhood,however,pathological mechanisms are not fully understood.At present,it is generally considered that autoimmune response leading to tissue damage is triggered by endogenous and exogenous antigens acting on susceptible individuals with genetic background.In recent years,vitamin D has become a hot drug at home and abroad because of its anti-infective and immunoregulatory mechanisms except of keeping the balance of calcium and phosphorus.Vitamin D plays a role in regulation mainly through the specific vitamin D receptor(VDR) on target cells,such as T cells,monocytes,antigen presenting cells.Many studies about rheumatic immune diseases have shown that vitamin D are associated with it,although studies between vitamin D and JIA are rare.And in this paper,the research progress of anti-infective and immunoregulatory mechanisms of vitamin D in juvenile rheumatoid arthritis will be introduced.