Animal models of infantile spasms / 国际儿科学杂志

ABSTRACT

Infantile spasms(IS),an age-dependent epileptic encephalopathy seen in infancy,is characterized by unique electro-clinical features and pharmacological reactions.Most conventional antiepileptic drugs are ineffective for IS.Hormonal treatment(including adrenocorticotropic hormone ACTH,and oral steroids)and vigabatrin(VGB) now widely used as first-line treatments for IS,have certain effects on IS,but the effect of these two options on long-term outcomes has not been established.The etiology of IS is variable.It is unclear that how a wide variety of conditions result a common phenotype.Ideal animal models can help to understand pathogenesis of disease and explore new therapies to improve the ultimate outcome.This review summarizes the research status of animal models of IS.