Clinical research progresses of tuberous sclerosis complex / 国际儿科学杂志

ABSTRACT

Tuberous sclerosis complex (TSC) is an autosomal dominant hereditary cutaneous neurological syndrome.The clinical manifestations of TSC are complex and diverse,and many of them are skin lesions,brain nodules,cardiac rhabdomyoma,pulmonary vascular lymphoma,renal vascular leiomyoma and other body multiple hamartoma lesions and neuropsychiatric symptoms.The current studis have found that TSC1 and TSC2 are their causative genes.The pathogenesis of TSC and the latest research are summarized.