Pathogenesis and recurrence factors in E2A-PBX1 fusion gene positive children with acute lymphoblastic leukemia / 国际儿科学杂志
International Journal of Pediatrics
;
(6): 776-778,782, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-692590
ABSTRACT
The translocation of(1;19)(q23;p13)leading to E2A-PBX1 gene fusion,is one of the most common translocations in pediatric B-ALL. Fusion of the E2A-PBX1 gene forms a specific transcription factor activating the pre-B cell receptor,allowing the pre-B cells to self-renew. This process acts as a leukemia initiation factor. Simultaneously,it can combine a second mutation to activate the genetic damage activating kinase driven signaling pathway. Thereby clonality of precursor B cells proliferated abnormally,which will lead to the occur-rence of leukemia. This article summarizes the secondary mutations and kinases associated with E2A-PBX1 posi-tive recurrent patients,and provides help for targeted therapy in recurrent patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
Language:
Chinese
Journal:
International Journal of Pediatrics
Year:
2018
Type:
Article
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