Study on relationship between serum IDO level and regulatory T cells in patients with ulcerative colitis / 国际检验医学杂志

ABSTRACT

Objective To study the relationship between serum indoleamine 2 ,3-dioxygenase(IDO) and the level of regulatory T cells(Treg) in the patients with ulcerative colitis (UC) .Methods Seventy cases of UC treated in the Hainan Provincial People′s Hospital from January 2015 to February 2017 were selected as the observation group .In the same period ,70 healthy volunteers undergoing physical examination were selected as the control group .The levels of serum IDO and Treg were compared between the two groups ,the expression levels of serum IDO and Treg in of the patients with different disease activity periods and different severity de-grees of UC were observed ,and the correlation between the level of serum IDO and the Treg expression level in the patients with UC was analyzed .Results The serum IDO level in the observation group was significantly increased compared with that in the control group ,while the Treg expression level decreased which compared with the control group ,the difference was statistically significant (P<0 .05) .The serum IDO level in the pa-tients with activity period of the observation group was significantly increased compared with that in the pa-tients with remission period ,but the Treg expression level was decreased compared with that in the patients with remission period ,the difference was significant (P<0 .05) .The serum IDO and Treg expression levels had statistical difference among different disease degrees in the patients with active UC (P<0 .05) .The serum IDO level in the moderate and severe groups increased which compared with that in the mild group ,while the Treg expression level was significantly decreased compared with that in the mild group ,the difference was sig-nificant (P<0 .05) .The level of serum IDO in the severe group was significantly higher than that in the mod-erate group ,while the Treg expression level was significantly lower than that in the moderate group ,the difference was statistically significant ( P < 0 .05 ) .Conducting the correlation analysis according to the Spearman method found that there was a negative correlation between the serum IDO level and the Treg ex-pression level in the patients with UC (r= -0 .798 ,P=0 .000) .Conclusion The level of serum IDO in the pa-tients with UC is negatively correlated with the Treg expression level ,which jointly influence the occurrence and development of UC .