Correlation between Hcy ,VitB12 and folic acid levels with Alzheimer′s Disease / 国际检验医学杂志

ABSTRACT

Objective To investigate the correlation between the levels of Hcy ,VitB12 and folic acid with Alzheimer′s Disease(AD) .Methods Fifty-four patients with AD in this hospital were extracted as the AD group by using cluster sampling method ,and contemporaneous 50 persons undergoing healthy physical exami-nation were selected as the control group .The levels of serum Hcy ,VitB12 and folic acid were detected in the two groups .Then the correlation among 3 indicators was analyzed .Results Compared with the control group , the level of serum Hcy in the AD group was significantly increased (P<0 .05) ,the VitB12 and folic acid levels in the AD group were significantly decreased compared with the control group (P<0 .05) .The serum Hcy lev-el was negatively correlated with VitB12 and folic acid levels (r= -0 .751 ,-0 .807 ,P<0 .05) .The area under the receiver operating characteristic curves (AUC) of Hcy ,VitB12 and folic acid and their combine detection in AD patients were 0 .897 ,0 .176 ,0 .204 and 0 .933 respectively .Conclusion Serum Hcy ,VitB12 and folic acid have clinical diagnosis value in AD ,and the 3-indicator combined detection can increase the diagnosis efficiency .