Coagulation index and ALC in children with lymphoma before and after chemotherapy changes and its clinical significance / 国际检验医学杂志

ABSTRACT

Objective To explore the changes of coagulation index and absolute neutrophil count(ANC) before and after chemotherapy in lymphoma and its clinical significance.Methods 80 cases of lymphoma chil-dren admitted in our hospital from February 2013 to February 2016 were selected as the observation group,In addition,50 healthy subjects were enrolled as control group.The levels of prothrombin time(PT),fibrinogen (FIB),activated partial thromboplastin time(APTT),ANC were compared between the two groups.Results The levels of coagulation,ANC in the observation group were significantly higher than those in the healthy control group,the difference was statistically significant(P<0.05).There were no significant differences in coagulation function,ANC levels between children with stage Ⅰ and Ⅱ(P>0.05).There was no significant difference between the two groups(P>0.05).The levels of coagulation,ANC in children with chemotherapy were significantly lower than those before chemotherapy(P<0.05).There was no significant difference in co-agulation function,ANC level between chemotherapy group and chemotherapy group before chemotherapy (P>0.05).Conclusion Coagulation function and ANC levels are correlated with chemotherapy efficacy in children with lymphoma.Detection of coagulation function and ANC level during chemotherapy is helpful for finding and preventing bleeding in children with lymphoma.