Analysis of the significance of thyroid stimulating hormone and thyroid hormone in thyroid carcinoma by ROC curve / 国际检验医学杂志

ABSTRACT

Objective To investigate the role of thyroid stimulating hormone and thyroid hormone in the diagnosis and differential diagnosis of thyroid carcinoma and thyroid benign lesions.Methods Using ROC curve analysis,70 cases of thyroid cancer patients(sthyoid cancer group)and 70 cases of benign thyroid lesions (benign thyoid disease group)in the hospital were enrolled in the study and analyzed,serum TSH,FT4and FT3levels were measured.The value of ROC curve in the diagnosis and differential diagnosis of thyroid carci-noma and thyroid benign lesions was analyzed.Results The level of TSH in thyroid cancer group was signifi-cantly higher than that in benign thyroid disease group,while the levels of FT3and FT4were significantly low-er than those of benign thyroid lesions(P<0.05).ROC curve analysis showed that the area under the TSH curve was 0.800,and the critical point was TSH 4.55 μIU/mL,with thyroid cancer as a diagonal.With benign thyroid lesions as the diagonal,the area under the FT3curve was 0.791,the critical point was 3.25 ng/mL,the area under the FT4curve was 0.861,and the critical point was 1.54 ng/dL.Conclusion TSH,FT3and FT4 can be used in the differential diagnosis of thyroid cancer and thyroid benign lesions.