Analysis on the results and establish the reference range of trace element in whole blood of pregnant women / 国际检验医学杂志

ABSTRACT

Objective The levels of multi-trace elements in whole blood of pregnant women in Zhejiang province were analyzed to establish the reference range for this population.Methods Routine physical exami-nation data of 21 151 pregnant women during January 2015 to September 2016 from Hangzhou Dian Medical Center were analyzed retrospectively.Three groups including early pregnancy group,middle pregnancy group and late pregnancy group were divided according to the pregnancy period.A total of 1 859 women range from 20 to 40 years old healthy without pregnant were selected as control group.The levels of copper(Cu),zinc (Zn),calcium(Ca),magnesium(Mg)and iron(Fe)in different pregnancy groups were analyzed statistically. The reference interval of each element in the early,middle and late pregnancy group should be established re-spectively if necessary.Results There were significant differences existed in the levels of Cu between early, middle,late pregnancy group and the control group(P<0.05).The levels of whole blood Cu increased gradu-ally with the time of pregnancy.Compared with the control group,the levels of Zn in other group were differ-ent,and the deficiency rates in early,middle,late pregnancy group were 5.6%,9.3% and 5.0% respectively. There was no significant difference in the level of Fe between the control group and the early pregnancy group (P=0.083).But the levels of Fe in middle and late pregnancy group showed significant difference with control group(P< 0.05).The reference ranges published in manufactures′ package inserts could not meet clinical needs.Conclusion The lack of trace elements existed in different stages of pregnancy.It′s important to moni-tor and analyze the levels of trace elements during each stages of pregnancy,and intervention measures should be done as necessary.T he taken of Cu supplement should based on its reference interval in each stage of preg-nancy respectively.T he taken of Fe supplement should based on the reference interval of healthy,reproductive-age w omen.