Effects of continuous renal replacement therapy on biochemical and physiological parameters of severe acute pancreatitis / 国际检验医学杂志

ABSTRACT

Objective To investigate the effects of continuous renal replacement therapy (CRRT) on biochemical and physiological indexes of severe acute pancreatitis (SAP) and its clinical efficacy.Methods Totally 98 patients with severe acute pancreatitis admitted in our hospital were divided into experimental group(n=49) and control group(n=49).The experimental group received CRRT and the control group did not receive.Heart rate,body temperature,blood routine,urine output,mean arterial pressure,liver function,blood biochemistry and arterial blood gas analysis before and after treatment in the two groups were measured and compared before and after treatment.Results In the experimental group,respiration,heart rate,oxygen partial pressure (PO2),carbon dioxide partial pressure (PCO2),alkali residual (BE) and pH were significantly improved at 12 h after treatment,and lasted until 36 h after treatment;the differences were statistically significant (P＜0.05).In the experimental group,blood calcium increased,creatinine,urea nitrogen and blood sugar level decreased significantly,blood potassium and blood sodium level were stable within 12 h after treatment,and the difference was statistically significant,compared with the control group (P＜0.05).In the experimental group,the alanine aminotransferase (ALT) decreased significantly after 36 h of treatment,and the difference was statistically significant(P＜0.05).There was a significant difference between the experimental group and the control group in the hematocrit (HTC) and white blood cell count (WBC) before treatment (P＜ 0.05).The platelet count (PLT) in the experimental group decreased within 12 h,and the difference was statistically significant before treatment(P＜0.05).Conclusion Compared with the conventional treatment,the therapeutic effect of CRRT on SAP is more significant.The improvement of the physiological and biochemical indexes of the patients is obvious,which is of great significance to the prognosis of the patients.