Detection value of autoantibodies and inflammatory factors in patients with lupus erythematosus / 国际检验医学杂志

ABSTRACT

Objective To investigate the clinical diagnosis value of autoantibodies and inflammatory factors in lupus erythematosus.Methods 50 patients with lupus erythematosus in the hospital from January 2015 to October 2016 were selected as the observation group,which was further divided into the active and non active subgroups according to the disease activity index of lupus erythematosus.Meanwhile 45 women undergoing healthy physical examination were selected as the control group.The anti nuclear antibody(ANA),anti dsD-NA antibody and anti Sm antibody,anti nucleosome antibody(AnuA),anti rRNP antibody and interleukin 1 beta(IL)-1,IL-6,IL-8,and tumor necrosis factor alpha(TNF-α)levels were detected.The detection results were statistically analyzed.Results Compared with the control group,the positive rates of ANA,anti-dsD-NA antibody,anti Sm antibody,AnuA and anti rRNP antibody,and levels of serum IL-1β,IL-6,IL-8 and TNF-α in the observation group were significantly increased,the difference was statistically significant(P<0.05). Adopting 5-autoantibodies combined detection in lupus erythematosus,the positive rate in the observation group was 100.00%;compared with the inactive lupus erythematosus subgroup,the positive rates of anti dsD-NA antibody and AnuA in the active stage subgroup were significantly increased,moreover serum IL-1β,IL-6, IL-8 and TNF-α levels were significantly increased,the difference was statistically significant(P<0.05).Con-clusion Autoantibodies and inflammatory factors have a certain value in the early diagnosis of lupus erythe-matosus.T he sensitivity of autoantibodies combined detection is high.