Effect of vitamin D supplementation combined with standard secondary prevention and treatment in patients with coronary heart disease / 国际检验医学杂志

ABSTRACT

Objective To analyze the clinical value of vitamin D supplementation combined with standard secondary prevention and treatment in patients with coronary heart disease(CHD).Methods 120 patients with CHD were divided into the control group and the observation group,60 cases in each group.Both groups were given the standard secondary prevention and treatment and the observation group were additionally given vitamin D supplementation.The changes of glucose and lipid metabolism and carotid plaque before and after treatment were compared between the two groups,and the incidence of readmission in the two groups was sta-tistically analyzed.Results After 6 and 12 months of treatment,the fasting blood glucose(FPG),2 h post-prandial blood glucose(2 h PG),carotid intima-media thickness(IM T),coronary plaque integral and high-sen-sitivity C reactive protein(hs-CRP)in the observation group were lower than those in the control group,while glycosylated hemoglobin(HbA1c),serum calcium and 25(OH)D3were higher than those in the control group (P<0.05);There were no significant differences between the two groups in the incidence rates of adverse car-diovascular events and readmission(P>0.05).Conclusion In the treatment of patients with CHD,vitamin D supplementation combined with standard secondary prevention and treatment can regulate glucose and lipid metabolism,delay the progression of carotid atherosclerosis and reduce the incidence of adverse cardiovascular events.