The effect of multi-modal analgesia on postoperative cortisol and inflammatory cytokines in patients with esophageal cancer / 国际检验医学杂志

ABSTRACT

Objective To investigate the effect of multimodal analgesia on postoperative pain,cortisol and inflammatory factor expression in patients with esophageal carcinoma.Methods Totally 80 patients with open thoracic and esophageal carcinoma were selected for elective surgery in the people′s Hospital of Xinjiang Uygur Autonomous Region from October 2015 to October 2016,randomLy divided into group C,Group M1, Group M2,group M3,each group of 20 cases.Group M1 was given intravenous parecoxib sodium and epidural fentanyl before surgery;group M2 received intravenous parecoxib sodium before surgery and epidural fentanyl after surgery;group M3 was given epidural fentanyl before surgery and intravenous parecoxib sodium after surgery;patients in group C received normal saline treatment.VAS of 8,12,24 and 48 h after surgery and pre-operative,postoperative,postoperative 24,48 h Cor,IL-6,TNF-α level were recorded and compared in four groups.Results 8,12,24 and 48 h after operation,the VAS score of the group M1,group M2,group M3 was significantly lower than that of the group C(P<0.05),the VAS score of the group M1 was significantly lower than that of the group M2 and group M3(P<0.05);24 h and 48 h after operation,the levels of Cor,IL-6 and TNF-α in the group M1,group M2 and group M3 were significantly lower than those in the group C(P<0.05).The levels of Cor,IL-6 and TNF-α in the group M1 were significantly lower than those in the group M 2 and group M3(P<0.05).Conclusion A variety of ways combined with analgesia can reduce postoperative pain in patients with esophageal cancer,help reduce stress and inflammatory factors.