The clinical value of cystatin C,homocysteine and urinary alkaline phosphatase in the diagnosis of diabetic nephropathy / 国际检验医学杂志

ABSTRACT

Objective To study the clinical value of cystatin C,homocysteine and urinary alkaline phospha-tase in the diagnosis of diabetic nephropathy,and provide the basis for clinical diagnosis of diabetes mellitus. Methods 60 cases of simple diabetic patients who were treated in our hospital from January 2015 to December 2016 were selected as diabetes mellitus,selected 60 cases with diabetic nephropathy as diabetic nephropathy group,60 cases of healthy subjects in our hospital as the control group.The levels of cystatin C,homocysteine and urinary alkaline phosphatase and the positive rate of the three groups were observed and compared with those of the control group.Results The results of cystatin C,homocysteine and urinary alkaline phosphatase were significantly higher in diabetes mellitus group and diabetic nephropathy group than those in control group(P<0.05).The positive rate of cystatin C,homocysteine and urinary alkaline phosphatase in diabetic group and diabetic nephropathy group was higher than that in control group,the difference was statistically significant(P<0.05).Conclusion Serum cystatin C,homocysteine and urinary alkaline phosphatase can be used in the clinical diagnosis of diabetic nephropathy,and it is worthy to be popularized in clinical application.