Changes of D-dimer and high sensitivity C reactive protein in patients with acute exacerbation of chronic obstructive pulmonary disease and their prognostic significance / 国际检验医学杂志

ABSTRACT

Objective Objective to investigate the changes of D-dimer and hypersensitivity C reactive pro-tein(CRP)in patients with acute exacerbation of chronic obstructive pulmonary disease(AECPOD)and their effects on prognosis.Methods From January 2014 to January 2016,104 cases of AECOPD patients were en-rolled in the study.According to the prognosis,they were divided into death group and survival group.D-di-mer and CRP were detected and the concentration changes were observed.Results There was no significant difference in CRP and D-dimer between the two groups on day 1 after admission(P> 0.05).While On the third day,the fifth day and the end of discharge,the concentrations of CRP and D-dimer in the death group were significantly higher than those in the survival group(P<0.05).Conclusion The continuous elevation of D-dimer and CRP suggests that the prognosis of AECOPD patients is poor,so the concentrations of D-dimer and CRP can reflect the severity of the patient′s condition and is helpful in the prognostic estimation.