Diagnostic value of thyroid autoantibodies in Hashimoto′s thyroiditis:a Meta analysis / 国际检验医学杂志

ABSTRACT

Objective To systematically evaluate the diagnosis value of thyroid autoantibodies in hashimo-to′s thyroiditis.Methods Through the systematic retrieval of the Chinese periodical full text database (CNKI),the full text database of Chinese sci-tech periodicals (VIP),the Wanfang database,the PubMed,EM-base,Scopus,Cochrane library,the database of academic dissertations at home and abroad,the database of the conference papers and so on,all formally published scientific research literature from the establishment of da-tabase to January 2017 were retrieved.The retrieval conditions included "thyroid autoantibody","thyroid per-oxidase antibody"or "TPOAb","thyroid globulin antibody" or "TGAb","thyroid microsome antibody" or "TMAb","thyrotropin receptor antibody"or "TRAb","Hashimoto""Mastitis"or "Hashimoto′s disease".The study that accorded with the standard,the data of thyroid autoantibodies,Hashimoto′s thyroiditis and other data were analyzed by Meta in order to find out the best clinical evidence.Results In the meta-analysis of 33 articles,the levels of thyroid peroxidase antibody (TPOAb),antithyroid globulin antibody (TGAb) and thy-rotropin receptor antibody (TRAb) in the patients with Hashimoto′s thyroiditis were significantly higher than those in the healthy control group.The positive rates of TPOAb,TGAb,TRAb and TMAb in the patients with Hashimoto′s thyroiditis group were higher than those in the healthy control group.The difference was statistically significant (P< 0.05).Conclusion Detection of thyroid autoantibodies TPOAb,TGAb,TRAb and TMAb has important clinical value in the diagnosis of Hashimoto′s thyroiditis.