Mucin in colonic polyps and its clinical significance / 国际检验医学杂志

ABSTRACT

Objective To evaluate the expression of mucin(MUC1,MUC2,MUC5AC and MUC6)in the pathological tissues of different colonic polyps,and to analyze the clinical value of mucin expression in colonic polyp transformation.Methods 120 cases of colonic polyps were selected treated from the First Hospital of Shijiazhuang in Hebeiin hospital from January 2013 to January 2015.According to histopathological diagnosis, there were 3 groups,40 patients with hyperplastic polyps,40 patients with tubular adenoma,40 patients with villous adenoma.The expression of MUC1,MUC2,MUC5AC and MUC6 in the pathogens were detected by immunohistochemistry.Results In normal colonic mucosa,MUC1,MUC5AC,MUC6 were not expressed,and MUC2 positive expression was detected.The positive expression rates of high expression of MUC1 and MUC6 were observed in tubular adenoma and villous adenoma,while the positive expression of MUC1 and MUC6 was not detected in proliferative polyps.MUC2 showed a high positive expression rate in hyperplastic polyps and adenomatous polyps,and the positive expression rate in proliferative polyps and adenomatous polypshyperplas-tic polyps and adenomatous polyps decreased gradually.MUC5AC was expressed in proliferative polyps and adenomatous polyps,and the expression of MUC5AC in proliferative polyps was significantly lower than that ofin adenomatous polyps.Conclusion The difference in the positive expression of MUC1,MUC2,MUC5AC and MUC6 in hyperplastic polyps and adenomatous polyps MUC1,MUC2,MUC5AC,MUC6 in hyperplastic polyps and adenomatous polyps is associated with the increased risk of mucosal or muscularis mucosa invasion in colonic polyps,w hich can be used as a biomarker for the clinical diagnosis of the development of colonic pol-yps.