Distribution and drug resistance of Streptococcus pneumoniae infection in 327 children / 国际检验医学杂志

ABSTRACT

Objective To analyze the distribution and drug resistance of Streptococcus pneumoniae in 0-14 year old children of 0 to 4 year-old in theour hospital.Methods S.pneumoniae were identified by using ma-trix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS).Drug suscepti-bility test was performed by using ATB STREP 5 for each isolate.Penicillin G minimum inhibitory concentra-tion (MIC) was performed by using E-test.Results A total of 327 strains of S.pneumoniae were isolated,a-mong which 287(87.8%)were from sputum,25(7.6%) from the ear secretions,10(2.9%) from the nasal sinuses puncture fluid,and 3(0.9%)from the blood.The most strains were isolated in spring(28.4%),and the least in winter (22%),and there was no significant difference in the separation rate among the four sea-sons (P<0.05).The sensitivity rate,intermediate rate and drug resistant rate of non meningitis S.pneumoni-ae strains to penicillin G were 97.9%,0.6%,1.5%,respectively.The resistance rates of the bacteria to eryth-romycin,clindamycin,compoundtrimethoprim sulfamethoxazole and tetracycline were relatively high,a small number of levofloxacin resistant strains were found,and vancomycin and quinopin /Dafoe-P resistant strains were not detected.The resistance rates of penicillin G,penicillin resistant Streptococcus pneumoniae (PRSP) and penicillin inter mediated Streptococcus pneumoniae (PISP)to amoxicillin and cefotaximeto were markedly higher than that of penicillin G sensitive Streptococcus pneumoniae (PSSP),and the difference was statistically significant (P<0.01).A total of 227 strains of multidrug resistance Streptococcus pneumoniae (69.4%)were isolated,which were resistant to erythromycin,tetracycline,trimethopri compoundm-sulfamethoxazol and clin-damycin(46.2%).Conclusion The drug resistance monitoring of Streptococcus pneumoniae in children can not be ignored.The drug resistance of the bacteria to penicillin G is low.Penicillin G is still a cheap and effec-tive drug for the treatment of Streptococcus pneumoniae infection.