Significance of cerebrospinal fluid albumin and immunoglobulin G in the diagnosis of nervous system inflammatory diseases / 国际检验医学杂志

ABSTRACT

Objective To investigate the significance of cerebrospinal fluid albumin (CAlb) and cerebrospi-nal fluid immunoglobulin G (CIgG ) in the diagnosis of nervous system inflammatory diseases .Methods A retrospective analysis of 104 patients with cerebrospinal fluid examination from April 2016 to March 2017 in the hospital who were divided into 59 cases of inflammatory disease and 45 cases of non-inflammatory .Blood clearance protein (SAlb) ,CAlb and G IgG were examined(QAlb=CAlb/SAlb) and compared .Results After logarithmic transformation ,ln(CIgG) 4 .36 ± 1 .00 ,ln(CAlb) 6 .31 ± 0 .77 ,ln(QAlb) 2 .57 ± 0 .79 in inflamma-tory group ,compared with non-inflammatory group ,ln(CIgG) 3 .53 ± 0 .59 ,ln(CAlb) 5 .52 ± 0 .50 ,ln(QAlb) 1 .88 ± 0 .47 ,the difference ,were statistically significant (P< 0 .05) .Conclusion The degree of blood-brain barrier damage is different in different nervous system diseases ,and the synthesis of IgG is different ,CIgG , CAlb ,QAlb can be used as an indicator to judge the blood-brain barrier damage ,and can also be used in the differential diagnosis of inflammatory and non-inflammatory diseases of the nervous system .The increase of CIgG also suggests that the occurrence of the disease may be related to autoimmunity .