Association of HindⅢ polymorphism in the lipoprotein lipase gene with diabetes mellitus :an updated Meta-analysis / 国际检验医学杂志

ABSTRACT

Objective An updated Meta-analysis was undertaken to evaluate the recent progress in the as-sociation of lipoprotein lipase (LPL) gene HindⅢ polymorphism with diabetes mellitus (DM).Methods Da-tabases including PubMed ,OvidSP ,Web of Science ,CBM ,CNKI and Wanfang were systemically searched to collect all case-control studies on the correlation between LPL HindⅢ polymorphism and DM.According to the selection criteria ,2 reviewers independently screened the literatures ,extracted data and evaluated the quali-ty of the included studies.Meta-analysis was completed by using Stata 14.0 software.Results 21 groups of data from 20 literatures were included with 2 634 DM patients and 3 375 controls.The results of meta-analysis showed that the frequencies of G allele (OR=0.83 ,95% CI0.69 -0.99 ,P=0.04) and the dominant model [(TG+GG) vs.TTOR=0.79 ,95% CI0.63-0.99 ,P=0.04] in DM patients were associated with the re-duction in the risk of DM.Compared with TT genotype ,plasma triglyceride levels were obviously reduced in DM patients with TG +GG genotype and GG genotype.Furthermore ,total cholesterol levels in DM patients with TG+GG genotype were markedly decreased ,while HDL-C levels were significantly increased in DM pa-tients with TG+ GG genotype.Conclusion The G allele and TG + GG genotype of LPL HindⅢ polymor-phism may be protective factors for DM ,which can reduce the risk of DM by ameliorating the abnormalities of lipid metabolism.However ,large-scale and high-quality clinical trials on the association between LPL HindⅢ polymorphism and DM are still needed for further clarification.