Distribution and drug resistance of pathogenic bacteria of ventilator associated infection in ICU patients with severe tumor in Chengdu area / 国际检验医学杂志

ABSTRACT

Objective To investigate the distribution and drug resistance of pathogenic bacteria associated with ventilator associated infection in Intensive Care Unit (ICU) patients with severe tumor in Chengdu area. Methods 846 patients with severe and critical tumors who underwent mechanical ventilation in ICU from Jan-uary 2013 to December 2016 in Chengdu area were enrolled in the study.84 sputum specimens from patients with ventilator associated infection were collected ,bacteria were isolated and identified ,Gram-negative bacteria drug sensitivity test was carried out by GN201 method ,Gram-positive bacteria drug sensitivity test was carried out by GP method ,and drug sensitivity test was carried out by paper diffusion method.Results There were 80 strains of pathogenic bacteria in the sputum specimens from 84 patients with infection related infection ,inclu-ding 54 Gram-negative bacteria (67.50%) ,21 Gram-positive bacteria (26.25%) ,and 5 fungi (6.25%).The resistance rates of major Gram-negative bacteria to ceftazidime and cefepime were higher ,and the resistance rates of Pseudomonas aeruginosa to ceftazidime and cefepime were 94.74% and 89.47%,respectively ,the re-sistance rates of K lebsiella pneumoniae to ceftazidime and cefepime were 87.50% and 93.75%,respectively , and the resistance rates of Acinetobacter Bauman to ceftazidime and cefimidime were 100.00% and 83.33%, respectively ;the resistance rates of the main Gram-positive bacteria to penicillin and erythromycin were high-er ,and the resistance rates of Staphylococcus aureus to penicillin and erythromycin were 80.00% and 90.00%respectively ,the resistance rates of Staphylococcus hemolytic to penicillin and erythromycin were 87.50% and 75.00% respectively.Conclusion The pathogenic bacteria of ventilator associated infection in ICU patients with severe tumor in Chengdu area were mainly Gram-negative bacteria ,which should be paid attention to ,and effective monitoring and prevention measures should be taken for the relevant factors.