The importance of serum IL-1β,TNF-α in diabetic retinopathy patients with hyperuricemia / 国际检验医学杂志

ABSTRACT

Objective To detected the levels of inflammatory markers in diabetic retinopathy (DR) patients with hyperuricemia(HUA) ,and to investigated the relationship between diabetic retinopathy and hyperurice-mia .Methods 190 DR patients were enrolled in to our study at January 2016 to June 2017 ,patients were di-vided into group of diabetic retinopathy with hyperuricemia (HUDR group) and group of diabetic retinopathy (DR group) according to level of serum UA ,and selected diabetes mellitus patient (DM group) and health per-son(HC group) as control group .Detected serum interleukin 1β(IL-1β) and tumor necrosis factor-α(TNF-α) levels of participants and statistical analysis .Results The IL-1β and TNF-α levels have significant difference between HUDR group ,DR group ,DM group and HC group ,the difference was statistically significant (P＜0 .05) ;Among them ,the levels of IL-1β 、TNF-α in HUDR group was significantly higher than that of DR group ,DM group and HC group ,and the difference was statistically significant (P＜0 .05) .The proportion of proliferative retinopathy in group HUDR was 42 .1%,was significantly higher DR group which was 27 .4%, the difference was statistically significant (P＝0 .033) .Serum UA level was positively corrected to IL-1β(r＝0 .356 ,P＝0 .000) and TNF-α(r＝0 .660 ,P＝0 .000) levels of HUDR patients .Logistic regression analysis re-veal that UA(OR1 .857 ,95% CI1 .123-3 .229) ,IL-1β(OR2 .124 ,95% CI1 .336-3 .715) and TNF-α(OR1 .673 ,95% CI1 .108 -2 .275) were independent risk factors of diabetic retinopathy .Conclusion There are higher levels of IL-1β and TNF-α in diabetic retinopathy patients with hyperuricemia ,hyperuricemia may pro-mote the progression of diabetic retinopathy and hyperuricemia is an independent risk factor of the disease .