Correlation analysis of serum interleukin 1β,C reactive protein and homocysteine levels in elderly patients with ischemic stroke after fatigue and ischemic stroke / 国际检验医学杂志

ABSTRACT

Objective To investigate the correlation between serum interleukin 1β (IL-1β) ,C reactive pro-tein (CRP) and homocysteine (Hcy) levels in elderly patients with ischemic stroke after fatigue and ischemic stroke .Methods 119 elderly patients with ischemic stroke were selected from our hospital from August 2016 to August 2017 .According to the fatigue severity scale ,40 cases were divided into fatigue group and 79 cases in non fatigue group .The peripheral blood samples were taken from the fasting blood in early morning ,and the serum levels of IL-1β ,CPR and Hcy were determined by enzyme linked immunosorbent assay (ELISA ) . Results The fatigue group ADL score ,Fugl-Meyer motor function of upper and lower limbs were lower than those of non fatigue group and control group ,the difference was statistically significant (non fatigue groupt＝23 .360 9 ,18 .203 6 ,9 .288 6 ,the control groupt＝39 .926 6 ,20 .260 3 ,21 .929 6 ,P＜0 .05) ;Non fatigue group ADL score ,Fugl-Meyer motor function of upper and lower limbs score lower than the control group ,the difference was statistically significant (t＝23 .021 4 ,6 .831 9 16 .810 3 ,P＜0 .05) .Fatigue serum IL-1β ,CPR and Hcy were higher than that in non fatigue group and control group ,the difference was statistically signifi-cant(non fatigue groupt＝14 .561 5 ,17 .029 6 ,13 .059 9 ,the control groupt＝31 .631 9 ,36 .998 3 ,33 .670 0 , P＜0 .05) ;Non fatigue group serum IL-1β ,CPR and Hcy were higher than that of control group ,the difference was statistically significant (t＝23 .866 0 ,28 .774 4 ,26 .135 4 ,P＜0 .05) .There was a positive linear correla- tion between fatigue and IL-1 beta ,CPR and Hcy in patients with ischemic stroke .Conclusion IL-1 ,CPR and Hcy levels in elderly patients with ischemic stroke fatigue were significantly elevated and it has obvious corre-lation .