Acquired Gitelman Syndrome
Electrolytes & Blood Pressure
;
: 5-8, 2009.
Article
in English
| WPRIM
| ID: wpr-69289
ABSTRACT
Acquired renal tubular disorder can be observed in various disease processes, especially autoimmune diseases. Gitelman syndrome is an autosomal recessive disease characterized by hypokalemic metabolic alkalosis, hypomagnesemia, and hypocalciuria. This disorder is caused by mutation in the SLC12A3 gene, which encodes the thiazide - ensitive NaCl cotransporter (NCCT). Acquired Gitelman syndrome has been reported and the majority has been associated with Sjogren's syndrome. The presence of circulating auto - antibodies to NCCT was suggested as a mechanism of acquired Gitelman syndrome. Treatment of acquired Gitelman syndrome was done with supplements of potassium and magnesium and prednisone was effective in some cases. Acquired Gitelman syndrome should be included in the differential diagnosis of renal involvement in patients with autoimmune diseases, especially Sjogren's syndrome.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Potassium
/
Autoimmune Diseases
/
Prednisone
/
Sjogren's Syndrome
/
Diagnosis, Differential
/
Alkalosis
/
Gitelman Syndrome
/
Magnesium
/
Antibodies
Type of study:
Diagnostic study
Limits:
Humans
Language:
English
Journal:
Electrolytes & Blood Pressure
Year:
2009
Type:
Article
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