Correlation between poststroke depression in acute phase of ischemic stroke and stroke recurrence at 1 year / 国际脑血管病杂志

ABSTRACT

Objective To investigate the correlation between poststroke depression (PSD) in acute phase of ischemic stroke and stroke recurrence at 1 year.Methods Consecutive patients with acute ischemic stroke were enrolled prospectively.Hamilton Depression Rating Scale and 1 year follow-up were conducted.Multivariate logistic regression was used to identify the independent correlation between stroke recurrence and PSD.Results A total of 331 patients with acute ischemic stroke were enrolled,in which 115 patients (34.7％) with PSD,37 (11.2％) had stroke recurrence in 1 year follow-up period.There were no significant differences in demography and baseline clinical data between the PSD group and the non-PSD group.The age (66.9 ± 11.7 years vs.59.7 ± 11.7 years;t =3.621,P＜0.001),systolic blood pressure (140.0 [133.5-150.0] mmHgvs.135 [127.0-146.0] mmHg;Z=2.302,P=0.021),as well as the proportions of patients with atrial fibrillation (24.3％ vs.9.5％;x2=7.251,P=0.007),diabetes (51.4％ vs.28.6％;x2=7.956,P=0.005) andPSD (17.4％ vs.7.9％;x2=6.852,P=0.009) in the stroke recurrence group were significantly higher than those in the non-recurrent group.Multivariate logistic regression analysis showed that PSD was an independent predictor of stroke recurrence after adjusting for age,systolic blood pressure,total cholesterol,atrial fibrillation,and diabetes (odds ratio 2.15,95％ confidence interval 1.19-5.45;P=0.016).Conclusion PSD in acute phase of ischemic stroke is independently correlated with stroke recurrence at 1 year.